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Understanding Oxygen Toxicity: Part 1 – Looking Back

In this first of a two-part series, Diver Alert Network’s Reilly Fogarty examines the research that has led to our current working understanding of oxygen toxicity. He presents the history of oxygen toxicity research, our current toxicity models, the external risk factors we now understand, and what the future of this research will look like. Mind your PO2s!

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By Reilly Fogarty

Header photo courtesy of DAN

Oxygen toxicity is a controversial subject among researchers and an intimidating one for many divers. From the heyday of the “voodoo gas” debates in the early 1990s to the cursory introduction to oxygen-induced seizure evolution that most divers receive in dive courses, the manifestations of prolonged or severe hyperoxia can often seem like a mysterious source of danger. 

Although oxygen can do great harm, its appropriate use can extend divers’ limits and improve the treatment of injured divers. The limits of human exposure are tumultuous, often far greater than theorized, but occasionally–and unpredictably–far less.  

Discussions of oxygen toxicity refer primarily to two specific manifestations of symptoms: those affecting the central nervous system (CNS) and those affecting the pulmonary system. Both are correlated (by different models) to exposure to elevated partial pressure of oxygen (PO2). CNS toxicity causes symptoms such as vertigo, twitching, sensations of abnormality, visual or acoustic hallucinations, and convulsions. Pulmonary toxicity primarily results in irritation of the airway and lungs and decline in lung function that can lead to alveolar damage and, ultimately, loss of function. 

The multitude of reactions that takes place in the human body, combined with external risk factors, physiological differences, and differences in application, can make the type and severity of reactions to hyperoxia hugely variable. Combine this with a body of research that has not advanced much since 1986, a small cadre of researchers who study these effects as they pertain to diving, and an even smaller group who perform research available to the public, and efforts to get a better understanding of oxygen toxicity can become an exercise in frustration. 

Piecing together a working understanding involves recognizing where the research began, understanding oxygen toxicity (and model risk for it) now, and considering the factors that make modeling difficult and increase the risk. This article is the first in a two-part series. It will cover the history of oxygen toxicity research, our current models, the external risk factors we understand now, and what the future of this research will look like. 

Early Research

After oxygen was discovered by Carl Scheele in 1772, it took just under a century for researchers to discover that, while the gas is necessary for critical physiological functions, it can be lethal in some environments. The first recorded research on this dates back to 1865, when French physiologist Paul Bert noted that “oxygen at a certain elevation of pressure, becomes formidable, often deadly, for all animal life” (Shykoff, 2019). Just 34 years later, James Lorrain Smith was working with John Scott Haldane in Belfast, researching respiratory physiology, when he noted that oxygen at “up to 41 percent of an atmosphere” was well-tolerated by mice, but at twice that pressure mouse mortality reached 50 percent, and at three times that pressure it was uniformly fatal (Hedley-White, 2008). 

Interest in oxygen exposure up to this point was largely medical in nature. Researchers were physiologists and physicians working to understand the mechanics of oxygen metabolism and the treatment of various conditions. World War II and the advent of modern oxygen rebreathers brought the gas into the sights of the military, with both Allied and Axis forces researching the effects of oxygen on divers. Chris Lambertsen developed the Lambertsen Amphibious Respiratory Unit (LARU), a self-contained rebreather system using oxygen and a CO2 absorbent to extend the abilities of U.S. Army soldiers, and personally survived four recorded oxygen-induced seizures. 

Kenneth Donald, a British physician, began work in 1942 to investigate cases of loss of consciousness reported by British Royal Navy divers using similar devices. In approximately 2,000 trials, Donald experimented with PO2 exposures of 1.8 to 3.7 bar, noting that the dangers of oxygen toxicity were “far greater than was previously realized … making diving on pure oxygen below 25 feet of sea water a hazardous gamble” (Shykoff, 2019). While this marked the beginning of the body of research that resembles what we reference now, Donald also noted that “the variation of symptoms even in the same individual, and at times their complete absence before convulsions, constitute[d] a grave menace to the independent oxygen-diver” (Shykoff, 2019). He made note not just of the toxic nature of oxygen but also the enormous variability in symptom onset, even in the same diver from day to day. 

The U.S. Navy Experimental Diving Unit (NEDU), among other groups in the United States and elsewhere, worked to expand that understanding with multiple decades-long studies. These studies looked at CNS toxicity in: immersed subjects with a PO2 of less than 1.8 from 1947 to 1986; pulmonary toxicity (immersed, with a PO2 of 1.3 to 1.6 bar, and dry from 1.6 to 2 bar) from 2000 to 2015; and whole-body effects of long exposures at a PO2 of 1.3 from 2008 until this year. 

The Duke Center for Hyperbaric Medicine and Environmental Physiology, the University of Pennsylvania, and numerous other groups have performed concurrent studies on similar topics, with the trend being a focus on understanding how and why divers experience oxygen toxicity symptoms and what the safe limits of oxygen exposure are. Those limits have markedly decreased from their initial proposals, with Butler and Thalmann proposing a limit of 240 minutes on oxygen at or above 25 ft/8 m and 80 minutes at 30 ft/9 m, to the modern recommendation of no greater than 45 minutes at a PO2 of 1.6 (the PO2 of pure oxygen at 20 ft/6 m). 

Between 1935 and 1986, dozens of studies were performed looking at oxygen toxicity in various facets, with exposures both mild and moderate, in chambers both wet and dry. After 1986, these original hyperbaric studies almost universally ended, and the bulk of research we have to work with comes from before 1986. For the most part, research after this time has been extrapolated from previously recorded data, and, until very recently, lack of funding and industry direction coupled with risk and logistical concerns have hampered original studies from expanding our understanding of oxygen toxicity. 

Primary Toxicity Models

What we’re left with are three primary models to predict the effects of both CNS and pulmonary oxygen toxicity. Two models originate in papers published by researchers working out of the Naval Medical Research Institute in Bethesda, Maryland, in 1995 (Harabin et al., 1993, 1995), and one in 2003 from the Israel Naval Medical Institute in Haifa (Arieli, 2003). The Harabin papers propose two models, one of which fits the risk of oxygen toxicity to an exponential model that links the risk of symptom development to partial pressure, time of exposure, and depth (Harabin et al., 1993). The other uses an autocatalytic model to perform a similar risk estimate on a model that includes periodic exposure decreases (time spent at a lower PO2). The Arieli model focuses on many of the same variables but attempts to add the effects of metabolic rate and CO2 to the risk prediction. Each of these three models appears to fit the raw data well but fails when compared to data sets in which external factors were controlled.  


Comparison of predicted and recorded oxygen toxicity incidents by proposed model (Shykoff, 2019).

The culmination of all this work and modeling is that we now have a reasonable understanding of a few things. First, CNS toxicity is rare at low PO2, so modeling is difficult but risk is similarly low. Second, most current models overestimate risk above a PO2 of 1.7 (Shykoff, 2019). This does not mean that high partial pressures of oxygen are without risk (experience has shown that they do pose significant risk), but the models cannot accurately predict that risk. Finally, although we cannot directly estimate risk based on the data we currently have, most applications should limit PO2 to less than 1.7 bar (Shykoff, 2019).  

NOAA Oxygen Exposure Limits  (NOAA Diving Manual, 2001).

For the majority of divers, the National Oceanic and Atmospheric Administration’s (NOAA) oxygen exposure recommendations remain a conservative and well-respected choice for consideration of limitations. The research we do have appears to show that these exposure limits are safe in the majority of applications, and despite the controversy over risk modeling and variability in symptom evolution, planning dives using relatively conservative exposures such as those found in the NOAA table provides some measure of safety. 

The crux of the issue in understanding oxygen toxicity appears to be the lack of a definitive mechanism for the contributing factors that play into risk predictions. There is an enormous variability of response to hyperoxia among individuals–even between the same individuals on different days. There are multiple potential pathways for injury and distinct differences between moderate and high PO2 exposures, and the extent of injuries and changes in the body are both difficult to measure and not yet fully understood. 

Interested in the factors that play into oxygen toxicity risk and what the future of this research holds? We’ll cover that and more in the second part of this article in next month’s edition of InDepth.

Additional Resources:

  1. Shykoff, B. (2019). Oxygen Toxicity: Existing models, existing data. Presented during EUBS 2019 proceedings.
  2. Hedley-Whyte, John. (2008). Pulmonary Oxygen Toxicity: Investigation and Mentoring. The Ulster Medical Journal 77(1): 39-42.
  3. Harabin, A. L., Survanshi, S. S., & Homer, L. D. (1995, May). A model for predicting central nervous system oxygen toxicity from hyperbaric oxygen exposures in humans
  4. Harabin, A. L., Survanshi, S. S. (1993). A statistical analysis of recent naval experimental diving unit (NEDU) single-depth human exposures to 100% oxygen at pressure. Retrieved from https://apps.dtic.mil/dtic/tr/fulltext/u2/a273488.pdf
  5. Arieli, R. (2003, June). Model of CNS O2 toxicity in complex dives with varied metabolic rates and inspired CO2 levels
  6. NOAA Diving Manual. (2001). 

Two Fun (Math) Things:

CALCULATOR FOR ESTIMATING THE RISK OF PULMONARY OXYGEN TOXICITY by Dr. Barbara Shykoff

The Theoretical Diver: Calculating Oxygen CNS toxicity


Reilly Fogarty is a team leader for risk mitigation initiatives at Divers Alert Network (DAN). When not working on safety programs for DAN, he can be found running technical charters and teaching rebreather diving in Gloucester, MA. Reilly is a USCG licensed captain whose professional background includes surgical and wilderness emergency medicine as well as dive shop management.

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My Deep Dive Into The Dunning-Kruger Effect

Tech diver Brendan Lund shares his personal diving journey from summitting Mount Stupid and descending into the depths of Despair on trimix, before finally beginning his ascent on the Slope of Enlightenment. No Kool-Aid was involved in the making of this story.

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by Brendan Lund
Images courtesy of Brendan Lund

Lund diving in Socorro, Mexico,

I started diving in 1996 as a poor student in South Africa. I absolutely fell in love with diving, and haven’t stopped since. After moving to the UK in 2001, I finally started earning money and was able to dive more frequently. At this time, the Red Sea was starting to boom, and I was able to book a full week of diving—including flight and accommodation—for as little as 350 GBP! Many trips later, I became interested in tech diving, as it was the happening thing, and in 2004 I decided to begin my tech journey with a leading agency. This also signals the start of my journey with the Dunning-Kruger Effect!

Grokking Dunning-Kruger 

I first saw the Dunning-Kruger effect graph a year or so ago and couldn’t stop thinking about its relationship to my diving. 

What is the Dunning-Kruger Effect? Here’s what Wikipedia has to say:

In the field of psychology, the Dunning–Kruger effect is a cognitive bias in which people with low ability at a task overestimate their ability. It is related to the cognitive bias of illusory superiority and comes from the inability of people to recognise their lack of ability.

As described by social psychologists David Dunning and Justin Kruger, the bias results from an internal illusion in people of low ability and from an external misperception in people of high ability; that is, ‘the miscalibration of the incompetent stems from an error about the self, whereas the miscalibration of the highly competent stems from an error about others’.

The graph below simplifies this concept—again, this is taken from the internet, but the wording pretty much sums up what I have been feeling throughout  this journey:

The less knowledge you have, the more confident you feel. The more you learn, the less confident you feel. 

The View from Mount Stupid

In 2005, I progressed from an advanced nitrox diver to a fully-certified advanced trimix diver. My instructor was a well-known deep diver at the time, and I was super impressed with the courses. I was at the point of Mount Stupid on the graph. These courses were not a pass/fail style of course; you just had to prove you could complete the skill once, and bam! You’re qualified! 

“Wow, I’m the man! I’ve passed my Advanced Trimix Course and dived to 100m.”

I dug out the photo below from a box in the shed. We had someone take an underwater photo of us celebrating our successful completion of our deco procedure course. As you may notice, trim was not a requirement at the time (I’m now hiding my face with embarrassment)! Apologies to my buddies in the photo; it was a while ago, and the instructor is the only one in reasonable trim!

Class celebrating the completion of a deco procedures course.

To say I was chuffed is an understatement! I immediately went tech diving as much as possible. In 2008, I decided to travel the world for a year—diving of course. I met many amazing people and dived everywhere; I also became an instructor with a well-known recreational agency. I was at the top of my game (or so I thought), although I still don’t think I had any trim! I mean, who needs trim, right?

On one of my adventures, I met a guy who was really interested in checking out a new agency that he had heard of. This would be the first time that I heard about Global Underwater Explorers (GUE). After much research and reading internet forums for GUE in 2000, I believe the Dunning-Kruger realisation phase of my journey began: I thought, “There is definitely a lot more to this!”

The Slope of Despair

I’m not going to lie; the more I looked into GUE, the more nervous I got, and the more I slid down the slope of despair. It took me a good six years to build up the courage to sign up for a Fundamentals class, and I showed up on that day feeling very confident in my brand new drysuit and my horseshoe wing. Wow, did I learn that I was way out of my depth! I was in trouble. It was so much harder than I had ever imagined. I don’t think it was so much the course that was hard, but that it was hard for me to overcome my ego and overconfidence.



I received a provisional “Tech Pass” [i.e., I qualified to take GUE’s Tech 1 or Cave 1], and it felt like I had failed! I was at the bottom of the Dunning-Kruger slope of despair.  Was I ever going to get it? I questioned whether I should go back to get my pass, and I have to thank my buddies Nikky and Darren for encouraging me to do so. After lots of practice and some gear tweaks, I felt like I smashed it, and achieved my Tech Pass! Was this the beginning of the slope of enlightenment? Things were starting to make sense!

The Slope of Enlightenment

I have now completed two more GUE classes—DPV1 and Cave 1—and am signed up for Tech 1 next year. The future looks bright! I dive as often as I can with like-minded divers, and I realize that there is always more to learn and areas where I can improve. I am hopeful that I am now on the Slope of Enlightenment; it certainly feels that way.

I highly recommend GUE to any divers that would like to work on themselves. It has definitely helped me on my diving journey, and I now look forward to many more years of diving and learning. I can’t wait to get involved in more projects and extend my skill set.

Additional Resources

It’s Never Too Late To Tackle Fundamentals


Brendan is an events manager based in London and (currently) dives mainly around the southwest coast of England. He started diving in 1996 in South Africa and has dived all around the world. He found a passion for cave diving a few years agohis favourite place to do this is Tulum, Mexicobut still loves wreck diving. Brendan is looking forward to the next challenge, with project work planned with Project Baseline, and Tech 1 is in his diary for next year in Croatia, since Covid-19 postponed it this year.

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